Regulation of neurotransmitter receptor activity

Across TCGA cell cohorts, RNA activity of the Regulation of neurotransmitter receptor activity pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM5, NEK6, and TAF10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBM5 grouped by Regulation of neurotransmitter receptor activity-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RBM5 →	-1.375	-1.966	<.001	<.001	3	4
LUNG_NSCLC_LUSC	NEK6 →	-1.428	-1.526	.003	.003	2	5
LARGE_INTESTINE	TAF10 →	-0.803	-0.938	<.001	.005	3	4
STOMACH	ARL6IP5 →	-1.342	-0.929	<.001	.003	3	3
STOMACH	IL18 →	-2.791	-0.919	.002	.004	3	3
STOMACH	RASSF7 →	-0.756	-0.941	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBM5 by Regulation of neurotransmitter receptor activity activity — BONE

Explore this box plot interactively →