Neurotransmitter receptor internalization

Across TCGA patient cohorts, RNA activity of the Neurotransmitter receptor internalization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNN2, CILP, and PHLDB1_S430, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter receptor internalization activity versus CNN2 in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNN2 →	+0.401	+0.029	<.001	<.001	3	6
BRCA	CILP →	+0.667	+0.031	<.001	<.001	3	6
LSCC	PHLDB1_S430 →	+0.998	+0.071	.003	<.001	3	5
LUAD	SLC9A7_S693 →	+0.498	+0.035	.002	.002	3	5
CCRCC	TAGLN_S166 →	+0.861	+0.039	.001	.004	3	5
LSCC	MRTO4 →	-0.360	-0.071	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099590 vs CNN2 — BRCA

Explore this scatter interactively →