Neurotransmitter receptor internalization

Across TCGA patient cohorts, RNA activity of the Neurotransmitter receptor internalization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBL2, DAAM2, and MYEOV, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter receptor internalization activity versus MYBL2 in LUAD (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MYBL2 →	-1.130	-0.247	<.001	.002	3	3
LUAD	DAAM2 →	+0.738	+0.332	<.001	.002	3	3
LUAD	MYEOV →	-1.432	-0.335	.003	.008	3	3
LUAD	EDDM3A →	+0.773	+0.188	<.001	.009	3	3
OV	SFTA2 →	+1.124	+0.116	.006	.006	3	3
LUAD	TEAD4 →	-0.508	-0.348	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099590 vs MYBL2 — LUAD

Explore this scatter interactively →