Neurotransmitter receptor internalization

Across TCGA cell cohorts, RNA activity of the Neurotransmitter receptor internalization pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP2M1, AP2S1, and TFRC, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AP2M1 grouped by Neurotransmitter receptor internalization-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	AP2M1 →	-0.762	-0.441	<.001	<.001	3	13
URINARY_TRACT	AP2S1 →	-0.517	-0.557	.004	<.001	2	11
LARGE_INTESTINE	TFRC →	-0.617	-0.728	<.001	.006	2	7
LUNG_NSCLC_LUAD	ACAD10 →	-0.159	-0.168	.005	.002	3	5
BLOOD_Leukemia	ACKR4 →	-0.186	-0.251	<.001	<.001	3	4
BLOOD_Leukemia	DGKQ →	-0.235	-0.251	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AP2M1 by Neurotransmitter receptor internalization activity — OVARY

Explore this box plot interactively →