Inorganic ion import across plasma membrane

Across TCGA patient cohorts, RNA activity of the Inorganic ion import across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAS1L, BRIX1, and EFTUD2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inorganic ion import across plasma membrane activity versus LAS1L in GBM (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LAS1L →	-0.298	-0.050	<.001	<.001	3	7
LSCC	BRIX1 →	-0.321	-0.040	<.001	<.001	3	6
GBM	EFTUD2 →	-0.301	-0.070	<.001	<.001	3	6
LSCC	CAD →	-0.311	-0.044	<.001	<.001	3	6
GBM	PES1 →	-0.347	-0.073	<.001	<.001	3	6
HNSC	TEX10 →	-0.278	-0.044	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099587 vs LAS1L — GBM

Explore this scatter interactively →