Inorganic ion import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Inorganic ion import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAST4, DNTT, and ANKH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAST4 grouped by Inorganic ion import across plasma membrane-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MAST4 →	-1.301	-0.931	.004	.005	2	5
OESOPHAGUS	DNTT →	-0.108	-0.688	<.001	.003	3	4
BLOOD_Leukemia	ANKH →	-2.038	-0.789	.007	.008	3	3
BLOOD_Leukemia	ARPP21 →	-2.749	-0.807	.008	.006	3	3
BLOOD_Leukemia	CYSLTR1 →	+2.080	+1.013	.008	.009	3	3
BLOOD_Leukemia	PRKCH →	-2.139	-0.854	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAST4 by Inorganic ion import across plasma membrane activity — PANCREAS

Explore this box plot interactively →