Inorganic ion import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Inorganic ion import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIR, BCKDK, and VIL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inorganic ion import across plasma membrane activity versus PIR in LIVER (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PIR →	+1.917	+0.360	<.001	<.001	3	4
LARGE_INTESTINE	BCKDK →	-0.818	-0.447	<.001	.001	3	4
LARGE_INTESTINE	VIL1 →	+3.350	+0.286	<.001	.006	3	4
LARGE_INTESTINE	ATP1B1 →	+1.368	+0.331	<.001	.001	3	4
LARGE_INTESTINE	GPX2 →	+4.782	+0.496	.001	.001	3	4
OVARY	LGR4 →	+2.472	+0.280	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099587 vs PIR — LIVER

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