Regulation of postsynaptic cytosolic calcium ion concentration

Across TCGA patient cohorts, RNA activity of the Regulation of postsynaptic cytosolic calcium ion concentration pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZDHHC5, HK1, and PLCH2_S595, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic cytosolic calcium ion concentration activity versus ZDHHC5 in PDAC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ZDHHC5 →	+0.244	+0.072	.009	.008	3	4
GBM	HK1 →	+0.528	+0.094	<.001	<.001	3	4
LUAD	PLCH2_S595 →	+0.594	+0.075	<.001	.002	3	4
HNSC	TIMM23 →	+0.266	+0.120	.001	<.001	3	3
HNSC	ZNF593 →	+0.323	+0.109	.006	.007	3	3
HNSC	CEP170B_S772 →	+0.512	+0.123	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099566 vs ZDHHC5 — PDAC

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