Regulation of postsynaptic cytosolic calcium ion concentration

Across TCGA cell cohorts, RNA activity of the Regulation of postsynaptic cytosolic calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOBP, LHX2, and WNT5B, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic cytosolic calcium ion concentration activity versus SOBP in LUNG_NSCLC_LUAD (Pearson r = -0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SOBP →	-0.935	-1.748	<.001	.002	3	1
LUNG_NSCLC_LUAD	LHX2 →	+3.765	+1.750	<.001	.001	2	1
LUNG_NSCLC_LUAD	WNT5B →	-2.594	-1.638	<.001	.004	2	1
LUNG_NSCLC_LUAD	NPR3 →	-4.040	-1.716	.006	.001	2	1
LUNG_NSCLC_LUAD	EFHD1 →	+3.175	+1.750	.002	.001	2	1
LUNG_NSCLC_LUAD	LRRC42 →	+0.725	+1.636	<.001	.004	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099566 vs SOBP — LUNG_NSCLC_LUAD

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