"Chemical synaptic transmission, postsynaptic"

Across TCGA patient cohorts, RNA activity of the "Chemical synaptic transmission, postsynaptic" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP2K4, MARVELD2_S161, and ATP6V0A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Chemical synaptic transmission, postsynaptic" activity versus MAP2K4 in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAP2K4 →	+0.663	+0.071	<.001	<.001	3	5
LSCC	MARVELD2_S161 →	-0.550	-0.022	<.001	.001	3	5
GBM	ATP6V0A1 →	+0.741	+0.058	<.001	<.001	3	5
GBM	PRR36 →	+0.489	+0.059	<.001	<.001	3	5
GBM	ROGDI →	+0.365	+0.047	<.001	<.001	3	4
LSCC	SENP2_S344 →	-0.332	-0.017	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099565 vs MAP2K4 — GBM

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