"Chemical synaptic transmission, postsynaptic"

Across TCGA patient cohorts, RNA activity of the "Chemical synaptic transmission, postsynaptic" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGTR1, NEK2, and TTK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Chemical synaptic transmission, postsynaptic" activity versus AGTR1 in BRCA (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AGTR1 →	+1.850	+0.406	.001	.006	3	6
LUAD	NEK2 →	-0.981	-0.625	<.001	.001	3	6
LUAD	TTK →	-0.911	-0.615	<.001	.001	3	6
BRCA	CASQ2 →	+0.662	+0.516	.003	.002	3	6
CCRCC	RAMP2 →	+0.808	+0.855	.001	.002	3	6
LSCC	CDK1 →	-0.873	-1.089	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099565 vs AGTR1 — BRCA

Explore this scatter interactively →