"Chemical synaptic transmission, postsynaptic"

Across TCGA cell cohorts, RNA activity of the "Chemical synaptic transmission, postsynaptic" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAP1GAP, PPARGC1B, and ADA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAP1GAP grouped by "Chemical synaptic transmission, postsynaptic"-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RAP1GAP →	+2.446	+1.151	<.001	<.001	3	4
BREAST	PPARGC1B →	+0.867	+0.812	.002	.008	3	4
STOMACH	ADA →	+1.878	+1.398	.002	<.001	3	4
BONE	MAGIX →	-0.631	-1.393	.005	.003	3	3
LUNG_SCLC	FAM117A →	-1.074	-0.982	.007	<.001	3	3
LIVER	AKIRIN2 →	-0.895	-1.240	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAP1GAP by "Chemical synaptic transmission, postsynaptic" activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →