"Chemical synaptic transmission, postsynaptic"

Across TCGA cell cohorts, RNA activity of the "Chemical synaptic transmission, postsynaptic" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPRIN2, FBXO10, and TGIF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Chemical synaptic transmission, postsynaptic" activity versus GPRIN2 in LUNG_NSCLC_LUAD (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPRIN2 →	-1.000	-0.434	.003	.006	3	5
CNS	FBXO10 →	-0.839	-0.853	.001	.004	3	4
LARGE_INTESTINE	TGIF1 →	-0.806	-0.299	<.001	<.001	3	4
LUNG_SCLC	HOXA9 →	-3.953	-0.934	<.001	.002	3	3
BLOOD_Myeloma	KCTD10 →	+0.724	+0.398	.002	.004	3	3
BLOOD_Myeloma	RHOG →	+1.028	+0.384	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099565 vs GPRIN2 — LUNG_NSCLC_LUAD

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