Modification of synaptic structure

Across TCGA patient cohorts, RNA activity of the Modification of synaptic structure pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S1438, ZNF281_T888, and TAF3_T339, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modification of synaptic structure activity versus MAP1B_S1438 in LSCC (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B_S1438 →	+0.853	+0.035	.001	.002	3	5
LUAD	ZNF281_T888 →	-0.410	-0.036	.007	.003	3	4
LSCC	TAF3_T339 →	-0.619	-0.080	<.001	<.001	3	4
LSCC	FAM83H_S813 →	+0.980	+0.044	.001	.002	3	4
COAD	LARP4_S597 →	+0.457	+0.038	.002	.002	3	4
PDAC	TAB1 →	+0.107	+0.028	.009	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099563 vs MAP1B_S1438 — LSCC

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