Modification of synaptic structure

Across TCGA patient cohorts, RNA activity of the Modification of synaptic structure pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOC6B, ISLR2, and PURG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modification of synaptic structure activity versus EXOC6B in LSCC (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EXOC6B →	+0.426	+0.217	.003	.005	3	4
UCEC	ISLR2 →	+0.746	+1.000	<.001	<.001	3	4
PDAC	PURG →	+0.232	+0.286	.001	.003	3	4
PDAC	RGS7 →	+0.476	+0.364	.001	<.001	3	4
PDAC	ORAI1 →	-0.233	-0.337	.005	<.001	3	4
PDAC	GPIHBP1 →	+0.310	+0.359	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099563 vs EXOC6B — LSCC

Explore this scatter interactively →