Modification of synaptic structure

Across TCGA cell cohorts, RNA activity of the Modification of synaptic structure pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF703, MTCL1, and FOXC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF703 grouped by Modification of synaptic structure-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZNF703 →	+1.524	+0.758	<.001	.002	3	5
BONE	MTCL1 →	-2.548	-1.551	.003	.005	3	4
BONE	FOXC1 →	-1.916	-1.703	.008	.003	3	4
SKIN	JRKL →	+0.535	+0.691	.005	.006	3	4
BLOOD_Lymphoma	JUND →	-2.745	-1.817	.001	.002	3	4
BONE	FCGRT →	+4.602	+1.998	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF703 by Modification of synaptic structure activity — SKIN

Explore this box plot interactively →