Synaptic membrane adhesion

Across TCGA patient cohorts, RNA activity of the Synaptic membrane adhesion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IL16, JAK3, and RASAL3_S988, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic membrane adhesion activity versus IL16 in LSCC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IL16 →	-0.435	-0.076	.003	<.001	3	7
CCRCC	JAK3 →	-0.494	-0.066	.001	.002	3	6
CCRCC	RASAL3_S988 →	-0.716	-0.070	<.001	.001	3	6
GBM	FERMT3 →	-0.454	-0.049	.001	<.001	3	6
BRCA	ZAP70 →	-0.462	-0.022	.003	.009	2	7
BRCA	RASAL3_S51 →	-0.331	-0.038	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099560 vs IL16 — LSCC

Explore this scatter interactively →