Synaptic membrane adhesion

Across TCGA patient cohorts, RNA activity of the Synaptic membrane adhesion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPARCL1, CNRIP1, and SCN7A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic membrane adhesion activity versus SPARCL1 in BRCA (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPARCL1 →	+1.228	+0.703	<.001	<.001	3	7
BRCA	CNRIP1 →	+0.662	+0.516	<.001	<.001	3	7
UCEC	SCN7A →	+1.075	+0.333	<.001	<.001	3	7
BRCA	COX7A1 →	+0.941	+0.585	<.001	<.001	3	7
UCEC	ADAMTS9-AS2 →	+0.782	+0.326	<.001	<.001	3	7
BRCA	STIL →	-0.566	-0.488	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099560 vs SPARCL1 — BRCA

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