Maintenance of synapse structure

Across TCGA cell cohorts, RNA activity of the Maintenance of synapse structure pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AFAP1L2, BOP1, and NEK11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maintenance of synapse structure activity versus AFAP1L2 in BONE (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	AFAP1L2 →	+1.530	+1.379	.005	.002	3	6
BREAST	BOP1 →	-0.811	-0.908	.001	.004	3	5
BREAST	NEK11 →	+0.922	+1.018	<.001	.001	3	4
BREAST	RPL8 →	-1.266	-1.368	<.001	<.001	2	5
BREAST	F8 →	+0.884	+1.048	.001	.003	3	4
SKIN	PRKAR2A →	-0.731	-0.839	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099558 vs AFAP1L2 — BONE

Explore this scatter interactively →