"Trans-synaptic signaling, modulating synaptic transmission"

Across TCGA patient cohorts, RNA activity of the "Trans-synaptic signaling, modulating synaptic transmission" pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GUCY1B1, GUCY1A1, and F2R, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Trans-synaptic signaling, modulating synaptic transmission" activity versus GUCY1B1 in LAML (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	GUCY1B1 →	+2.154	+0.397	<.001	<.001	3	34
LAML	GUCY1A1 →	+2.438	+0.384	<.001	<.001	3	33
THYM	F2R →	+1.773	+0.083	<.001	<.001	3	30
MESO	PDGFRB →	+1.909	+0.085	<.001	<.001	3	29
COAD	ITGA4 →	+0.861	+0.063	<.001	<.001	3	28
TGCT	ADAMTS7 →	+1.224	+0.062	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099550 vs GUCY1B1 — LAML

Explore this scatter interactively →