"Trans-synaptic signaling, modulating synaptic transmission"

Across TCGA patient cohorts, RNA activity of the "Trans-synaptic signaling, modulating synaptic transmission" pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GUCY1A1, GUCY1B1, and PLAT, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Trans-synaptic signaling, modulating synaptic transmission" activity versus GUCY1A1 in CCRCC (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	GUCY1A1 →	+0.491	+0.088	<.001	.001	3	8
GBM	GUCY1B1 →	+0.400	+0.091	<.001	<.001	3	7
BRCA	PLAT →	+0.907	+0.073	<.001	<.001	3	6
GBM	RASAL2 →	+0.233	+0.085	<.001	<.001	3	6
LUAD	IL1RAP →	+0.361	+0.071	.002	.001	3	6
PDAC	PLXNA1 →	+0.411	+0.079	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099550 vs GUCY1A1 — CCRCC

Explore this scatter interactively →