"Trans-synaptic signaling, modulating synaptic transmission"

Across TCGA patient cohorts, RNA activity of the "Trans-synaptic signaling, modulating synaptic transmission" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, CNTN4, and EDIL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Trans-synaptic signaling, modulating synaptic transmission" activity versus CNRIP1 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNRIP1 →	+0.723	+0.512	<.001	<.001	3	6
CCRCC	CNTN4 →	+0.767	+0.410	<.001	.004	3	6
BRCA	EDIL3 →	+1.647	+0.550	<.001	<.001	3	6
CCRCC	TLL1 →	+1.224	+0.361	<.001	.008	3	6
OV	DACT3 →	+0.743	+0.581	<.001	<.001	3	6
OV	PLAT →	+1.087	+0.724	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099550 vs CNRIP1 — BRCA

Explore this scatter interactively →