"Trans-synaptic signaling, modulating synaptic transmission"

Across TCGA patient cohorts, RNA activity of the "Trans-synaptic signaling, modulating synaptic transmission" pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRMP1, GUCY1A2, and ARHGAP6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Trans-synaptic signaling, modulating synaptic transmission" activity versus CRMP1 in CCRCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CRMP1 →	+0.792	+0.543	<.001	<.001	3	5
UCEC	GUCY1A2 →	+0.447	+0.603	<.001	<.001	3	5
UCEC	ARHGAP6 →	+0.560	+0.695	<.001	<.001	3	5
CCRCC	PLAT →	+0.870	+0.412	<.001	<.001	3	5
GBM	SEPTIN4 →	+0.668	+0.708	<.001	<.001	3	4
CCRCC	TLN2 →	+0.551	+0.518	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099550 vs CRMP1 — CCRCC

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