Trans-synaptic signaling by trans-synaptic complex

Across TCGA patient cohorts, RNA activity of the Trans-synaptic signaling by trans-synaptic complex pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPHB2, FN1, and CEP170, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trans-synaptic signaling by trans-synaptic complex activity versus EPHB2 in LUAD (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EPHB2 →	+0.421	+0.079	<.001	<.001	3	7
BRCA	FN1 →	+0.841	+0.056	<.001	<.001	3	7
BRCA	CEP170 →	+0.358	+0.050	<.001	<.001	3	6
HNSC	ENPP1 →	+0.580	+0.076	<.001	.001	3	6
BRCA	GPX7 →	+0.436	+0.047	<.001	<.001	3	6
HNSC	DBN1 →	+0.440	+0.075	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099545 vs EPHB2 — LUAD

Explore this scatter interactively →