Trans-synaptic signaling by trans-synaptic complex

Across TCGA patient cohorts, RNA activity of the Trans-synaptic signaling by trans-synaptic complex pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAB39L, CKB, and SLAMF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trans-synaptic signaling by trans-synaptic complex activity versus CAB39L in BRCA (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAB39L →	+0.862	+0.611	<.001	<.001	3	5
OV	CKB →	+0.989	+0.697	<.001	<.001	3	4
GBM	SLAMF1 →	-0.279	-0.147	.002	.006	3	4
PDAC	SWAP70 →	-0.304	-0.691	<.001	<.001	3	3
PDAC	TAOK3 →	-0.258	-0.426	.002	.004	3	3
PDAC	ITGB1BP2 →	-0.189	-0.406	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099545 vs CAB39L — BRCA

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