Trans-synaptic signaling by trans-synaptic complex

Across TCGA cell cohorts, RNA activity of the Trans-synaptic signaling by trans-synaptic complex pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAG1, IER3IP1, and DNAH2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trans-synaptic signaling by trans-synaptic complex activity versus PLAG1 in LARGE_INTESTINE (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLAG1 →	-1.322	-1.612	<.001	.002	3	5
PANCREAS	IER3IP1 →	+1.291	+1.622	<.001	<.001	3	4
LUNG_NSCLC_LUAD	DNAH2 →	-2.560	-1.186	<.001	<.001	3	4
KIDNEY	ANKRD50 →	+1.162	+1.573	<.001	.005	3	3
SOFT_TISSUE	CHCHD7 →	-1.890	-1.508	.003	.001	2	4
CNS	ACP3 →	-0.597	-1.245	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099545 vs PLAG1 — LARGE_INTESTINE

Explore this scatter interactively →