Trans-synaptic signaling by lipid

Across TCGA patient cohorts, RNA activity of the Trans-synaptic signaling by lipid pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FABP5, PLCB1, and STAT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trans-synaptic signaling by lipid activity versus FABP5 in GBM (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FABP5 →	+0.732	+0.075	<.001	<.001	3	5
BRCA	PLCB1 →	+0.436	+0.033	<.001	<.001	3	5
COAD	STAT2 →	-0.214	-0.037	.007	.008	3	4
COAD	ABHD10 →	+0.249	+0.056	.004	.001	3	4
PDAC	HSPB1 →	+0.366	+0.055	.001	<.001	3	4
COAD	ANTXR2 →	-0.392	-0.085	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099541 vs FABP5 — GBM

Explore this scatter interactively →