Trans-synaptic signaling by lipid

Across TCGA patient cohorts, RNA activity of the Trans-synaptic signaling by lipid pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEMA4A, RNF214_S54, and ARHGAP23_S647, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trans-synaptic signaling by lipid activity versus SEMA4A in LUAD (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SEMA4A →	+0.521	+0.556	<.001	<.001	3	3
LUAD	RNF214_S54 →	-0.468	-0.435	<.001	<.001	3	3
GBM	ARHGAP23_S647 →	+0.493	+0.948	<.001	<.001	3	3
BRCA	CCDC86_S58 →	-0.873	-0.157	<.001	<.001	3	3
GBM	SPTAN1_S2066 →	+0.536	+0.840	<.001	<.001	3	3
GBM	MED10 →	-0.226	-0.668	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099541 vs SEMA4A — LUAD

Explore this scatter interactively →