Trans-synaptic signaling by lipid

Across TCGA cell cohorts, RNA activity of the Trans-synaptic signaling by lipid pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP21, MBNL3, and MATN4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP21 grouped by Trans-synaptic signaling by lipid-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	USP21 →	+0.602	+0.892	.002	.003	3	4
BLOOD_Leukemia	MBNL3 →	+1.222	+1.111	.006	.006	3	4
STOMACH	MATN4 →	+0.094	+1.019	.007	.006	3	4
OVARY	SYPL1 →	+0.888	+1.234	.002	.001	3	3
BLOOD_Myeloma	HMMR →	+1.217	+1.553	.009	.006	3	3
BLOOD_Lymphoma	DNAJC5 →	+0.543	+1.813	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP21 by Trans-synaptic signaling by lipid activity — OESOPHAGUS

Explore this box plot interactively →