Synaptic signaling via neuropeptide

Across TCGA patient cohorts, RNA activity of the Synaptic signaling via neuropeptide pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYP, TGFBI, and CACNA2D2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic signaling via neuropeptide activity versus SYP in GBM (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SYP →	+1.146	+0.660	<.001	<.001	3	4
GBM	TGFBI →	-1.636	-0.837	<.001	<.001	3	4
PDAC	CACNA2D2 →	+0.716	+0.925	<.001	<.001	3	4
GBM	FSTL4 →	+1.246	+0.821	<.001	<.001	3	4
GBM	PAK5 →	+1.110	+0.894	<.001	<.001	3	3
PDAC	PRSS3 →	+1.359	+0.604	.007	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099538 vs SYP — GBM

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