Synaptic signaling via neuropeptide

Across TCGA cell cohorts, RNA activity of the Synaptic signaling via neuropeptide pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LACC1, STK17B, and LOXL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LACC1 grouped by Synaptic signaling via neuropeptide-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LACC1 →	-1.995	-1.529	.001	.005	3	5
CNS	STK17B →	+0.981	+0.900	.001	.002	3	4
SKIN	LOXL2 →	-2.895	-1.026	<.001	<.001	3	3
SKIN	ATP6V0D1 →	+0.558	+1.018	.005	.004	3	3
SKIN	BCL2L13 →	+0.488	+0.849	.003	.007	3	3
BLOOD_Leukemia	CHML →	-1.135	-0.935	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LACC1 by Synaptic signaling via neuropeptide activity — BLOOD_Lymphoma

Explore this box plot interactively →