Synaptic signaling via neuropeptide

Across TCGA cell cohorts, RNA activity of the Synaptic signaling via neuropeptide pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBPJL, SLC7A7, and ACO2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBPJL grouped by Synaptic signaling via neuropeptide-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RBPJL →	+0.154	+2.233	.001	<.001	3	4
URINARY_TRACT	SLC7A7 →	-0.150	-0.265	.001	.002	3	3
LUNG_SCLC	ACO2 →	+0.494	+2.013	<.001	<.001	3	3
BLOOD_Leukemia	S1PR1 →	+0.218	+1.398	.001	.002	3	3
LUNG_SCLC	RNASE9 →	+0.137	+1.640	.008	.002	3	3
UPPER_AERODIGESTIVE_TRACT	RPS12 →	-0.224	-0.133	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBPJL by Synaptic signaling via neuropeptide activity — BONE

Explore this box plot interactively →