Synaptic vesicle endosomal processing

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle endosomal processing pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITSN1, VTI1A, and AP3D1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITSN1 grouped by Synaptic vesicle endosomal processing-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ITSN1 →	-0.425	-1.537	.001	<.001	3	10
BLOOD_Leukemia	VTI1A →	-0.337	-1.229	<.001	<.001	3	6
SKIN	AP3D1 →	-0.212	-1.337	.001	<.001	3	5
BLOOD_Leukemia	ATF1 →	+0.270	+1.514	<.001	<.001	3	5
SOFT_TISSUE	SYK →	-0.199	-1.011	.004	.001	3	5
BLOOD_Leukemia	PRSS12 →	-0.360	-1.561	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITSN1 by Synaptic vesicle endosomal processing activity — BLOOD_Leukemia

Explore this box plot interactively →