Synaptic vesicle endosomal processing

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle endosomal processing pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR1B, GALC, and COL5A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FCGR1B grouped by Synaptic vesicle endosomal processing-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FCGR1B →	-0.168	-0.763	.007	.005	3	4
LIVER	GALC →	+0.082	+1.440	.001	.001	3	3
BLOOD_Leukemia	COL5A3 →	+0.146	+1.062	.007	.003	3	3
BLOOD_Leukemia	SRPK1 →	+0.420	+1.170	.002	.002	3	3
OVARY	NOVA1 →	-0.254	-0.956	.002	.002	3	3
LUNG_SCLC	GAL →	+0.264	+1.272	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FCGR1B by Synaptic vesicle endosomal processing activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →