Synaptic vesicle endosomal processing

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle endosomal processing pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEA1, RAB31, and C12orf66, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle endosomal processing activity versus EEA1 in SKIN (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EEA1 →	+1.234	+0.985	<.001	<.001	3	5
LUNG_SCLC	RAB31 →	+2.548	+0.963	.002	.002	3	5
LARGE_INTESTINE	C12orf66 →	+0.514	+1.053	.001	<.001	3	5
BREAST	VANGL2 →	-2.276	-1.087	.002	.001	3	5
OVARY	IFNLR1 →	-1.396	-1.012	.001	.003	3	5
LUNG_SCLC	YPEL3 →	-1.578	-0.984	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099532 vs EEA1 — SKIN

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