Actin filament-based transport

Across TCGA patient cohorts, RNA activity of the Actin filament-based transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPN, VAV1, and CORO1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin filament-based transport activity versus SPN in GBM (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPN →	+0.595	+0.072	<.001	<.001	3	6
GBM	VAV1 →	+0.591	+0.077	<.001	<.001	3	6
LSCC	CORO1A →	+0.564	+0.067	<.001	<.001	3	6
LSCC	DOCK10 →	+0.434	+0.061	<.001	<.001	3	6
GBM	DOCK8 →	+0.507	+0.073	<.001	<.001	3	6
GBM	GRAP2 →	+0.894	+0.137	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099515 vs SPN — GBM

Explore this scatter interactively →