Actin filament-based transport

Across TCGA patient cohorts, RNA activity of the Actin filament-based transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRP1, RCCD1, and SNRPA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin filament-based transport activity versus RRP1 in UCEC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RRP1 →	-0.859	-0.809	<.001	<.001	3	5
UCEC	RCCD1 →	-0.665	-1.097	<.001	<.001	3	5
OV	SNRPA1 →	-0.740	-0.224	<.001	<.001	3	5
GBM	RAB27A →	+0.416	+0.131	.002	<.001	3	5
UCEC	ZNF7 →	-0.284	-0.833	.003	<.001	3	4
LSCC	ZNF887P →	-0.817	-0.224	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099515 vs RRP1 — UCEC

Explore this scatter interactively →