Synaptic vesicle cytoskeletal transport

Across TCGA patient cohorts, RNA activity of the Synaptic vesicle cytoskeletal transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP2_S833, MAP2, and MAP2_T1649, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle cytoskeletal transport activity versus MAP2_S833 in OV (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MAP2_S833 →	+0.926	+0.042	.003	<.001	3	8
LSCC	MAP2 →	+0.831	+0.057	<.001	<.001	3	7
LSCC	MAP2_T1649 →	+1.178	+0.054	<.001	<.001	3	7
LSCC	MAP2_S1155 →	+1.580	+0.058	<.001	<.001	3	6
LSCC	CNKSR2_S908 →	+1.629	+0.095	<.001	<.001	3	5
HNSC	MAP2_T290 →	+1.005	+0.062	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099514 vs MAP2_S833 — OV

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