Synaptic vesicle cytoskeletal transport

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle cytoskeletal transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRSF7, TMPRSS11B, and IMMT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRSF7 grouped by Synaptic vesicle cytoskeletal transport-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SRSF7 →	-0.385	-0.989	.003	.004	3	5
SKIN	TMPRSS11B →	+0.187	+1.310	.005	.001	3	4
LUNG_NSCLC_LUSC	IMMT →	-0.256	-1.235	.006	.002	3	3
LUNG_NSCLC_LUSC	CSNK1G2 →	-0.165	-1.103	.008	.005	3	3
BLOOD_Myeloma	ALKBH4 →	+0.196	+1.450	.001	.003	3	3
LUNG_NSCLC_LUSC	ASAH2 →	-0.293	-1.418	.007	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRSF7 by Synaptic vesicle cytoskeletal transport activity — BREAST

Explore this box plot interactively →