Synaptic vesicle cytoskeletal transport

Across TCGA cell cohorts, RNA activity of the Synaptic vesicle cytoskeletal transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD50, ALKBH8, and AP3S1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synaptic vesicle cytoskeletal transport activity versus ANKRD50 in CNS (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ANKRD50 →	+0.735	+0.208	.006	.009	3	4
LARGE_INTESTINE	ALKBH8 →	+0.574	+0.280	.005	.001	3	4
BREAST	AP3S1 →	+0.802	+0.265	.001	<.001	3	3
BREAST	NPIPB15 →	-1.065	-0.221	.009	.001	3	3
BREAST	NPIPB9 →	-0.762	-0.297	.005	.005	3	3
BLOOD_Leukemia	PITHD1 →	-0.459	-0.500	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099514 vs ANKRD50 — CNS

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