Regulation of presynaptic membrane potential

Across TCGA patient cohorts, RNA activity of the Regulation of presynaptic membrane potential pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPN7, MAP4K1, and BRAF, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of presynaptic membrane potential activity versus PTPN7 in BRCA (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PTPN7 →	-0.562	-0.070	<.001	.001	3	6
BRCA	MAP4K1 →	-0.679	-0.072	<.001	<.001	3	5
BRCA	BRAF →	+0.318	+0.070	<.001	.003	3	5
PDAC	PTPN22_S449 →	-0.523	-0.021	.006	.007	3	5
GBM	TRIOBP →	-0.316	-0.141	<.001	<.001	3	5
COAD	COL14A1 →	-0.729	-0.062	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099505 vs PTPN7 — BRCA

Explore this scatter interactively →