Regulation of presynaptic membrane potential

Across TCGA patient cohorts, RNA activity of the Regulation of presynaptic membrane potential pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STXBP5L, CATSPER2, and ADAM23, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of presynaptic membrane potential activity versus STXBP5L in GBM (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STXBP5L →	+0.791	+0.609	<.001	<.001	3	4
GBM	CATSPER2 →	+0.455	+0.664	.001	<.001	3	4
PDAC	ADAM23 →	+0.606	+0.188	<.001	.003	3	3
PDAC	TBX22 →	+0.036	+0.196	.004	.002	3	3
GBM	MTUS2 →	+0.748	+0.720	<.001	<.001	3	3
GBM	RAB3C →	+1.394	+0.664	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099505 vs STXBP5L — GBM

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