Vesicle fusion to plasma membrane

Across TCGA cell cohorts, RNA activity of the Vesicle fusion to plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2AK4, BCL2L13, and INTS14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle fusion to plasma membrane activity versus EIF2AK4 in LUNG_NSCLC_LUAD (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EIF2AK4 →	+0.776	+0.892	.002	.004	3	5
BLOOD_Lymphoma	BCL2L13 →	+0.642	+1.128	.007	.006	3	4
SKIN	INTS14 →	+0.718	+1.383	.001	.001	3	4
SKIN	CZIB →	+0.385	+1.058	<.001	.003	3	4
SKIN	PTPN9 →	+1.218	+1.445	<.001	<.001	3	4
SOFT_TISSUE	SNAP23 →	+1.048	+1.595	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099500 vs EIF2AK4 — LUNG_NSCLC_LUAD

Explore this scatter interactively →