Postsynaptic cytoskeleton organization

Across TCGA patient cohorts, RNA activity of the Postsynaptic cytoskeleton organization pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OSTF1, VCL_S272, and LARP6_S56, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic cytoskeleton organization activity versus OSTF1 in PDAC (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	OSTF1 →	+0.206	+0.047	.002	.004	3	5
COAD	VCL_S272 →	-0.501	-0.049	<.001	<.001	3	4
LUAD	LARP6_S56 →	-0.507	-0.072	<.001	.001	3	4
CCRCC	IRS2 →	-0.694	-0.060	.002	.007	2	5
CCRCC	IRS2_S608 →	-0.746	-0.069	.005	.001	3	4
HNSC	IRS2_S594 →	-0.644	-0.075	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099188 vs OSTF1 — PDAC

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