Postsynaptic cytoskeleton organization

Across TCGA patient cohorts, RNA activity of the Postsynaptic cytoskeleton organization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMM8A, ANKS1B, and LDB3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic cytoskeleton organization activity versus TIMM8A in GBM (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TIMM8A →	-0.290	-0.213	<.001	.007	3	5
GBM	ANKS1B →	+1.136	+0.263	<.001	<.001	3	5
HNSC	LDB3 →	+1.386	+0.389	<.001	.001	3	4
GBM	SHISAL1 →	+1.030	+0.187	<.001	.002	3	4
GBM	RCAN2 →	+1.531	+0.361	<.001	<.001	3	4
HNSC	ATP1A2 →	+1.708	+0.416	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099188 vs TIMM8A — GBM

Explore this scatter interactively →