Postsynaptic cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Postsynaptic cytoskeleton organization pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPATA33, KIFC2, and CALD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPATA33 grouped by Postsynaptic cytoskeleton organization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SPATA33 →	-0.908	-0.269	.004	.005	3	4
LARGE_INTESTINE	KIFC2 →	-0.959	-0.191	.005	.003	3	3
LUNG_SCLC	CALD1 →	-3.773	-0.366	.002	.005	2	4
LUNG_SCLC	CALU →	-1.162	-0.646	.001	.004	3	3
OESOPHAGUS	EVC2 →	-1.513	-0.473	.003	<.001	3	3
LUNG_NSCLC_LUAD	FBXL15 →	-0.789	-0.245	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPATA33 by Postsynaptic cytoskeleton organization activity — OESOPHAGUS

Explore this box plot interactively →