Postsynaptic cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Postsynaptic cytoskeleton organization pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HERC4, AGBL3, and DBI, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic cytoskeleton organization activity versus HERC4 in CNS (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HERC4 →	+0.928	+0.181	<.001	.004	3	6
LUNG_NSCLC_LUAD	AGBL3 →	+0.438	+0.189	<.001	<.001	3	5
BLOOD_Myeloma	DBI →	+1.640	+0.484	.002	.002	3	5
URINARY_TRACT	TRAK2 →	+0.868	+0.420	<.001	<.001	3	5
LUNG_NSCLC_LUSC	RAB8B →	+2.427	+0.487	.001	.003	2	6
LUNG_NSCLC_LUSC	TAX1BP1 →	+1.189	+0.386	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099188 vs HERC4 — CNS

Explore this scatter interactively →