Regulation of postsynapse organization

Across TCGA patient cohorts, RNA activity of the Regulation of postsynapse organization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNA5SP449, STIL, and RAB19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynapse organization activity versus RNA5SP449 in COAD (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNA5SP449 →	+0.439	+0.302	<.001	<.001	3	3
BRCA	STIL →	-0.760	-0.479	.001	.003	3	3
BRCA	RAB19 →	+0.741	+0.451	<.001	<.001	3	3
OV	SLC43A1 →	+0.527	+0.218	.003	.007	3	3
LUAD	TSEN15 →	-0.544	-2.094	.002	.005	3	3
HNSC	RN7SKP35 →	+0.951	+0.243	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099175 vs RNA5SP449 — COAD

Explore this scatter interactively →