Regulation of postsynapse organization

Across TCGA cell cohorts, RNA activity of the Regulation of postsynapse organization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMC6, MTERF3, and BTN2A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMC6 grouped by Regulation of postsynapse organization-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TMC6 →	-3.423	-0.310	.002	.003	3	5
BLOOD_Lymphoma	MTERF3 →	+1.200	+0.245	.002	.003	3	4
LUNG_NSCLC_LUAD	BTN2A1 →	+0.518	+0.112	.009	.009	2	4
LIVER	VPS26A →	+0.861	+0.337	.003	.007	2	4
BLOOD_Lymphoma	EBAG9 →	+1.120	+0.245	.001	.003	3	3
PANCREAS	PRDX3 →	+0.978	+0.196	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMC6 by Regulation of postsynapse organization activity — STOMACH

Explore this box plot interactively →