Regulation of postsynapse organization

Across TCGA cell cohorts, RNA activity of the Regulation of postsynapse organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFB1I1, EHD2, and ACVR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynapse organization activity versus TGFB1I1 in LUNG_NSCLC_LUSC (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TGFB1I1 →	+2.501	+0.164	.005	.004	3	6
LUNG_NSCLC_LUSC	EHD2 →	+3.475	+0.164	.004	.004	3	6
LUNG_NSCLC_LUSC	ACVR1 →	+0.914	+0.160	.006	.005	3	5
SOFT_TISSUE	JTB →	-0.529	-0.172	.006	.006	3	5
BLOOD_Lymphoma	STX2 →	+0.680	+0.196	.005	.001	3	5
OESOPHAGUS	AMOT →	-1.344	-0.146	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099175 vs TGFB1I1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →